Performing integrated systems biology

Molecular-based disease stratification

Identifying disease predictors and therapeutic targets

Creating translational research pipelines

THE MiKTMC MISSION

The goal of the Michigan Kidney Translational Medicine Core is to define chronic organ dysfunction in mechanistic terms and use this knowledge for targeted therapeutic interventions.

To reach this goal we have developed a translational research pipeline centered on integrated systems biology analysis of renal disease.

OUR INTEGRATED SYSTEMS BIOLOGY APPROACH

We are working towards molecular-based disease stratification.

Our general approach involves correlating clinical, molecular, and histopathologic phenotyping, along with validation in model systems.

Follow @MiKTMC on Twitter

RESEARCH NEWS

How the UMMS Central Biorepository Can Benefit Your Research

University of Michigan Medical School Office of Research recently published a video featuring the UMMS Central Biorepository (CBR). Director Victoria Blanc, Ph.D., walks through the process of accessing and storing biospecimens and MiKTMC’s Matthias Kretzler, MD speaks about how the samples from our cohort study networks across the world are managed using the CBR.

The Nephrotic Syndrome Research Network is revolutionizing the field of glomerular kidney disease research

Now in its ninth year, the benefits of laying the groundwork for the Nephrotic Syndrome Research Network (NEPTUNE) are beginning to come into fruition. As NephCure CEO Josh Tarnoff notes, “It’s hard to overstate NEPTUNE’s impact on our understanding of FSGS and related syndromes. For example, one of the data sets presented by NEPTUNE at ASN Kidney Week 2016 provided the much-needed evidence correlating proteinuria levels to survival. This no doubt assisted the FDA to evolve their guidelines to accept proteinuria…

U-M ENTERS COLLABORATION TO DEVELOP TREATMENTS FOR CHRONIC KIDNEY DISEASE

Patients with Chronic Kidney Disease (CKD) may benefit from a new collaboration between U-M and AstraZeneca, who have partnered to develop a new therapeutic strategy for treatment. The partners will jointly conduct chemistry and drug discovery research with the aim of developing candidate drugs. CKD …

Recent Publications

Office

4544 MSRB II
1150 W. Medical Center Drive
Ann Arbor, MI 48109

734-615-5757

Assistant: Jody Fisher

Lab

1552 MSRB II
1150 W. Medical Center Drive
Ann Arbor, MI 48109

734-764-2924

NEPTUNE Administration

A520C MSRB I
1150 W. Medical Center Drive
Ann Arbor, MI 48109

734-615-5020
734-615-5021

neptune-study@umich.edu

https://neptune-study.org